Population Pharmacokinetic - Pharmacodynamic Analysis of Voriconazole and Anidulafungin in 1 Adult Patients with Invasive
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Population Pharmacokinetic-Pharmacodynamic Analysis of Voriconazole and Anidulafungin in 1 Adult Patients with Invasive Aspergillosis 2 Ping Liu and Diane R. Mould 3 4 Clinical Pharmacology, Global Established Pharma Business, Pfizer Inc., Groton, CT, USA 5 Projections Research Inc., Phoenixville, PA, USA 6 7 8 Running title: Population PK-PD analysis of voriconazole and anidulafungin in IA patients 9
منابع مشابه
Population Pharmacokinetic - Pharmacodynamic Analysis of Anidulafungin in Adult Patients with 1 Fungal Infections
Population Pharmacokinetic-Pharmacodynamic Analysis of Anidulafungin in Adult Patients with 1 Fungal Infections 2 Ping Liu 3 4 Clinical Pharmacology, Specialty Care, Pfizer Inc, Groton, CT, USA 5 6 7 Running title: Population PK-PD analysis of anidulafungin 8
متن کاملPopulation pharmacokinetic-pharmacodynamic analysis of anidulafungin in adult patients with fungal infections.
To evaluate the exposure-response relationships for efficacy and safety of intravenous anidulafungin in adult patients with fungal infections, a population pharmacokinetic-pharmacodynamic (PK-PD) analysis was performed with data from 262 patients in four phase 2/3 studies. The plasma concentration data were fitted with a previously developed population PK model. Anidulafungin exposures in patie...
متن کاملIdentification of factors influencing the pharmacokinetics of voriconazole and the optimization of dosage regimens based on Monte Carlo simulation in patients with invasive fungal infections.
OBJECTIVES The objective of this study was to estimate the population pharmacokinetics of voriconazole, to identify the factors influencing voriconazole pharmacokinetics and to identify optimal dosage regimens for attaining target pharmacokinetic/pharmacodynamic indices against Aspergillus and Candida infections in patients with invasive fungal infections (IFIs). METHODS To prospectively quan...
متن کاملScreening for diabetes mellitus in patients with OSAS: a case for glycosylated haemoglobin.
nazole for prevention of invasive pulmonary aspergillosis. Antimicrob Agents Chemother 2009; 53: 2613–2615. 4 Tolman JA, Nelson NA, Son YJ, et al. Characterization and pharmacokinetic analysis of aerosolized aqueous voriconazole solution. Eur J Pharm Biopharm 2009; 72: 199–205. 5 Crandon JL, Banevicius MA, Fang AF, et al. Bronchopulmonary disposition of intravenous voriconazole and anidulafungi...
متن کاملCombination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis.
Voriconazole is a first-line agent for the treatment of invasive pulmonary aspergillosis. Isolates with elevated voriconazole MICs are increasingly being seen, and the optimal treatment regimen is not defined. We investigated whether the combination of voriconazole with anidulafungin may be beneficial for the treatment of A. fumigatus strains with elevated voriconazole MICs. We used an in vitro...
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تاریخ انتشار 2014